Swr1 subfamily
The archetype of the Swr1 subfamily is Swr1p
(SWI/SNF-related protein) from S cerevisiae which is
part of the large SWR1 complex that exchanges histone
H2A.Z-containing for wild type H2A-containing dimers
1, 2, 3, 4.
Three other characterised proteins belong to the
subfamily:
PIE1 is involved in the A thaliana vernalisation
regulation (Photoperiod-Independent Early flowering
5) through a pathway
intimately linked with histone lysine methylation
events 6.
D melanogaster Domino is an essential,
development-linked protein 7 and alleles can
suppress position effect variegation, implying they
may be linked to heterochromatin functions. Domino
participates in a complex that combines components
of the homologous yeast SWR1 and NuA4 complexes
8, and has been
shown to function in acetylation dependent histone
variant exchange within the TRRAP/TIP60 complex
9.
Human SRCAP (Snf2p-Related CBP Activating Protein
10) acts as a
transcriptional co-activator of steroid hormone
dependent genes and has recently been shown to be a
component of a human TRRAP/TIP60 complex 11 and other
complexes (see EP400 below). It also interacts with
several coactivators including CBP 10, 12. It has recently
been shown that SRCAP can rescue D melanogaster
domino mutants 13.
names associated with subfamilies members
SRCAP, Snf2-related CBP activator protein, dom,
domino, PIE1
references
1: Krogan, N. J., M. C.
Keogh, et al. (2003). A Snf2 family ATPase
complex required for recruitment of the histone
H2A variant Htz1. Mol Cell 12(6): 1565-76.
PubMed
2: Kobor, M. S., S.
Venkatasubrahmanyam, et al. (2004). A protein
complex containing the conserved
Swi2/Snf2-related ATPase Swr1p deposits histone
variant H2A.Z into euchromatin. PLoS Biol 2(5):
E131.
PubMed
3: Mizuguchi, G., X.
Shen, et al. (2004). ATP-driven exchange of
histone H2AZ variant catalyzed by SWR1 chromatin
remodeling complex. Science 303(5656): 343-8.
PubMed
4: Wu, W. H., S. Alami,
et al. (2005). Swc2 is a widely conserved
H2AZ-binding module essential for ATP-dependent
histone exchange. Nat Struct Mol Biol 12(12):
1064-71.
PubMed
5: Noh, Y. S. and R. M.
Amasino (2003). PIE1, an ISWI family gene, is
required for FLC activation and floral
repression in Arabidopsis. Plant Cell 15(7):
1671-82.
PubMed
6: He, Y. and R. M.
Amasino (2005). Role of chromatin modification
in flowering-time control. Trends Plant Sci
10(1): 30-5.
PubMed
7: Ruhf, M. L., A. Braun,
et al. (2001). The domino gene of Drosophila
encodes novel members of the SWI2/SNF2 family of
DNA-dependent ATPases, which contribute to the
silencing of homeotic genes. Development 128(8):
1429-41.
PubMed
8: Doyon, Y. and J. Cote
(2004). The highly conserved and multifunctional
NuA4 HAT complex. Curr Opin Genet Dev 14(2):
147-54.
PubMed
9: Kusch, T., L. Florens,
et al. (2004). Acetylation by Tip60 is required
for selective histone variant exchange at DNA
lesions. Science 306(5704): 2084-7.
PubMed
10: Johnston, H., J.
Kneer, et al. (1999). Identification of a novel
SNF2/SWI2 protein family member, SRCAP, which
interacts with CREB-binding protein. J Biol Chem
274(23): 16370-6.
PubMed
11: Cai, Y., J. Jin, et
al. (2005). The mammalian YL1 protein is a
shared subunit of the TRRAP/TIP60 histone
acetyltransferase and SRCAP complexes. J Biol
Chem 280(14): 13665-70.
PubMed
12: Monroy, M. A., N. M.
Schott, et al. (2003). SNF2-related CBP
activator protein (SRCAP) functions as a
coactivator of steroid receptor-mediated
transcription through synergistic interactions
with CARM-1 and GRIP-1. Mol Endocrinol 17(12):
2519-28.
PubMed
13: Eissenberg, J. C., M.
Wong, et al. (2005). Human SRCAP and Drosophila
melanogaster DOM are homologs that function in
the notch signaling pathway. Mol Cell Biol
25(15): 6559-69.
PubMed
