Chd1 subfamily
The archetype of the Chd1 subfamily is mouse Chd1,
named from the presence of ‘Chromodomain,
Helicase and DNA binding’ motifs 1. The
characteristic chromodomains can in principle bind
diverse targets including proteins, DNA and RNA
2. It has previously
been recognised that the Chd1-related proteins fall
into the same 3 groupings 3, 4 which were
distinguished in this analysis.
Chd1 proteins have been purified as single subunits
5, 6. However,
subsequently associations between Chd1 and other
proteins have been identified 7, 8. Yeast Chd1 has
been implicated in transcription elongation and
termination 9, 10. Further Chd1
subfamily members are the human CHD1 and CHD2
proteins and D melanogaster dChd1 which have been
linked to transcriptional events 11. S pombe Chd1
subfamily member hrp1 (helicase related protein 1)
has been linked with both transcription termination
9 and chromosome
condensation 12, whereas hrp3 has
been linked with locus-specific silencing 13.
References
1: Delmas, V., D. G.
Stokes, et al. (1993). A mammalian DNA-binding
protein that contains a chromodomain and an
SNF2/SWI2-like helicase domain. Proc Natl Acad
Sci U S A 90(6): 2414-8.
PubMed
2: Brehm, A., K. R.
Tufteland, et al. (2004). The many colours of
chromodomains. Bioessays 26(2): 133-40.
PubMed
3: Woodage, T., M. A.
Basrai, et al. (1997). Characterization of the
CHD family of proteins. Proc Natl Acad Sci U S A
94(21): 11472-7.
PubMed
4: Tajul-Arifin, K., R.
Teasdale, et al. (2003). Identification and
analysis of chromodomain-containing proteins
encoded in the mouse transcriptome. Genome Res
13(6B): 1416-29.
PubMed
5: Tran, H. G., D. J.
Steger, et al. (2000). The chromo domain protein
chd1p from budding yeast is an ATP-dependent
chromatin-modifying factor. Embo J 19(10):
2323-31.
PubMed
6: Lusser, A., D. L.
Urwin, et al. (2005). Distinct activities of
CHD1 and ACF in ATP-dependent chromatin
assembly. Nat Struct Mol Biol 12(2): 160-6.
PubMed
7: Krogan, N. J., M. Kim,
et al. (2002). RNA polymerase II elongation
factors of Saccharomyces cerevisiae: a targeted
proteomics approach. Mol Cell Biol 22(20):
6979-92.
PubMed
8: Pray-Grant, M. G., J.
A. Daniel, et al. (2005). Chd1 chromodomain
links histone H3 methylation with SAGA- and
SLIK-dependent acetylation. Nature 433(7024):
434-8.
PubMed
9: Alen, C., N. A. Kent,
et al. (2002). A role for chromatin remodeling
in transcriptional termination by RNA polymerase
II. Mol Cell 10(6): 1441-52.
PubMed
10: Krogan, N. J., M.
Kim, et al. (2003). Methylation of histone H3 by
Set2 in Saccharomyces cerevisiae is linked to
transcriptional elongation by RNA polymerase II.
Mol Cell Biol 23(12): 4207-18.
PubMed
11: Kelley, D. E., D. G.
Stokes, et al. (1999). CHD1 interacts with SSRP1
and depends on both its chromodomain and its
ATPase/helicase-like domain for proper
association with chromatin. Chromosoma 108(1):
10-25.
PubMed
12: Walfridsson, J., P.
Bjerling, et al. (2005). The CHD remodeling
factor Hrp1 stimulates CENP-A loading to
centromeres. Nucleic Acids Res 33(9): 2868-79.
PubMed
13: Jae Yoo, E., Y. Kyu
Jang, et al. (2002). Hrp3, a chromodomain
helicase/ATPase DNA binding protein, is required
for heterochromatin silencing in fission yeast.
Biochem Biophys Res Commun 295(4): 970-4.
PubMed
